Kevin Blackwell admitted a number of the squad had shown signs of the virus and he would have to leave naming a team until the last moment for the visit of Plymouth.
Blackwell said in the Yorkshire Evening Post: "We've had a few down with flu, but the next 24 hours are a worry because you don't know who else will pick it up.
"It's impossible to name a team at this stage because it all depends on who is well and who isn't. I planned to make a few changes anyway, but I might have to make a few more now. The flu bug will affect what I do."