Jason Scotland gave Ipswich a first-half lead before Leeds poached an equaliser through Robert Snodgrass.
But, after former Ipswich defender Alex Bruce had been sent off for a second yellow card, Tommy Smith was afforded the freedom of the Leeds penalty area to head home the winner.
Yet Grayson was at least able to reflect on an improvement following the 6-4 defeat by Preston last time out.
"I thought we were quite comfortable, even though we were behind at half-time," he said."Our goalkeeper didn't have too many saves to make and we looked solid. There was a response from the team, after the other night."
Source: PA
Source: PA