In the North East Sunderland play host to Hartlepool, while Telford United's reward for reaching round three is a trip to Gresty Road to face Crewe Alexandra.
Accrington Stanley will be at home to Colchester United if they see off Bournemouth in a replay, while there are another four all-Premiership ties apart from the Elland Road highlight.
Southampton host Newcastle United and Manchester United go to Aston Villa in another all Premiership clash.
Full Draw:
Wimbledon v Stoke City
Cardiff City v Sheffield United
Wycombe Wanderers or Mansfield Town v Burnley
Crewe Alexandra v Telford United
Bristol City or Barnsley v Scunthorpe or Sheffield Wednesday
Portsmouth v Blackpool
Northampton Town v Rotherham United
Fulham v Cheltenham Town
Manchester City v Leicester City
Southampton v Newcastle United
Yeovil Town v Liverpool
Birmingham City v Blackburn Rovers
Nottingham Forest v West Brom
Watford v Chelsea
Kidderminster Harriers v Wolves
Gillingham v Charlton Athletic
Swansea City v Macclesfield Town or Cambridge United
Leeds United v Arsenal
Tottenham Hotspur v Crystal Palace
Aston Villa v Manchester United
Southend United v Scarborough
Sunderland v Hartlepool United
Tranmere Rovers v Bolton Wanderers
Preston North End v Reading
Wigan Athletic v West Ham
Middlesbrough v Notts County
Ipswich Town v Derby County
Coventry City v Peterborough United
Everton v Norwich City
Bournemouth or Accrington Stanley v Colchester United
Bradford City v Luton Town
Millwall v Walsall