Rovers have been a division higher than their county neighbours ever since their famous League One play-off success over the Whites at Wembley in 2008.
However, Leeds have now joined Doncaster in the Championship, although Ryan believes Rovers' playing squad is superior.
The Rovers supremo is surprised Leeds fans from Doncaster support the West Yorkshire club ahead of Friday's meeting.
"All these people who pretend to support Leeds and come from Doncaster, it's quite unbelievable," said Ryan. "If you are from Doncaster you should support Doncaster Rovers! We're better than Leeds anyway!
"I'm sure it will be a tremendous atmosphere inside the Keepmoat Stadium. Obviously all of the Leeds fans are going to be there but I really think we've got a quality team this year and I'm sure we're going to give Leeds an awful lot to think about.
"I would imagine if I was a betting man that Rovers would be favourites against Leeds on Friday night, which would almost be a unique situation."