Paul Robinson sits out the clash due to a one match ban. Mark Viduka is also suspended thanks to the Australian football authorities.
Eirik Bakke (thigh) and Didier Domi (ankle) should be fit but Lucas Radebe (hamstring) is still a doubt while Jody Morris and Michael Duberry are both out.
Ole Gunnar Solskjaer may return to Manchester United's line-up after five months out following knee surgery.
Louis Saha is available after being cup-tied last week while Wes Brown is likely to start on the bench.
Manchester Utd (from): Howard, Carroll, G Neville, Silvestre, Brown, O'Shea, Fortune, P Neville, Forlan, Ronaldo, Fletcher, Scholes, Butt, Keane, Solskjaer, Kleberson, Giggs, van Nistelrooy, Saha, Bellion.
Leeds (from): Carson, Kelly, Harte, Camara, Radebe, Caldwell, Barmby, Olembe, Pennant, McPhail, Smith, Bakke, Johnson, Matteo, Lennon, Domi, Richardson, Sakho, Kilgallon, Milner, Allaway.