Mark De Vries - on loan at Elland Road from Leicester City - is ineligible having been unavailable for the original tie at Hereford on November 9, and the same rule will keep Radostin Kishishev sidelined.
Kishishev extended his loan with Leeds from Leicester until January 23 yesterday and has been given permission to play in the FA Cup, but he was not free to play in the game at Edgar Street and will enter the competition if United reach the next round.
Ian Westlake (broken toe) and Tore Andre Flo (foot) are also out of action, although Flo is now aiming to return from his persistent problem before Christmas.
Captain Alan Thompson is nearing full fitness but may be forced to settle for a place on the bench with Jonny Howson in fine touch.
Jamie Clapham is available for the final time before he concludes his long-term loan from Wolves, but his imminent departure could see Wise turn instead to Ben Parker on the left side of defence.
Curtis Weston is competing for a place on the right wing in the absence of Prutton.
The Whites (from): Ankergren, Richardson, Madden, Heath, Marques, Huntington, Clapham, Parker, Thompson, Hughes, Howson, Weston, Carole, Kandol, Beckford, Constantine, Lucas.