The sides have never met in this competition and the last time Leeds played there proved to be Peter Reid's last game in charge when The Whites were humiliated 6-1.
The game will be played in the week commencing October 25.
FULL DRAW
Portsmouth v Leeds
Chelsea v West Ham
Middlesbrough v Coventry
Doncaster v Nottm Forest
Newcastle v Norwich
Millwall v Liverpool
Burnley v Aston Villa
Southampton v Colchester
Sheff United v Watford
Everton v Leicester or Preston
Charlton v Crystal Palace
Bolton v Tottenham
Bournemouth v Cardiff
Man City v Arsenal
Birmingham v Fulham
Crewe v Man Utd